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Post Doc call - Define the molecular signature of the muscle-nerve interplay and in the pathogenesis of ALS

BC:67966

The Istituto Italiano di Tecnologia is a private law Foundation, created with special Government Law no. 269 of September 30th 2003, with the objective of promoting Italy's technological development and higher education in science and technology. Research at IIT is carried out in highly innovative scientific fields with state-of-the-art technology.

A postdoctoral position will be available starting from October 1st 2013 in the Center for Life Nanoscience at the Istituto Italiano di Tecnologia (CLNS@SAPIENZA), Rome, Italy to work on the generation and characterization of novel transgenic animal models of ALS disease and on the development of in vitro cell co-culture systems to study the interplay between muscle and nerve.

A crucial aspect of the project deals with setting up appropriate cellular and animal model systems where to study the activity of wild type and mutant ALS-associated proteins.

An important aspect of the project is to develop/improve cell culture technology (bi - and 3 dimensional co-culture systems) between myogenic and neuronal cells to mimic -in an ex vivo system- the physiopathologic interplay between muscle and nerve, to study and better manipulate the critical signals emanating from the two tissues, and to define potential diagnostic tools for classifying the progression of the disease.

The project also aims to produce transgenic mice with ubiquitously and/or locally expressed wild type and TDP-43A315T proteins. Morphological, functional and molecular analysis will be performed to characterize possible alterations at level of muscle, NMJ, and spinal cord of novel transgenic mice. Moreover possible alterations in the embryonic myogenic program and muscle regeneration will be evaluated.

Ideal candidates should have a PhD in Biology and/or Embryology and/or Biotechnology and a solid background in cell and molecular biology and embryology, as well as specific experience with:

  • generation and manipulation of mouse animal models
  • muscle cell culture systems (2D and 3D)
  • muscle-nerve co-culture
  • analysis of gene and protein expression

A good knowledge of English is essential.

We value scientists with a proactive attitude and results-oriented mindset, good interpersonal and communications skills and ability to work effectively within an interdisciplinary research team.

The employment will be for 3 years. An internationally competitive salary, dependent on experience, will be offered.

Interested applicants should submit CV, list of publications, a statement of research interests, and the names of at least two referees both to Prof. Giancarlo Ruocco (This email address is being protected from spambots. You need JavaScript enabled to view it.) and Dr. Andrea D’Aiello (This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it.).

Please, mention “Post Doc call in “Define the molecular signature of the muscle-nerve interplay and in the pathogenesis of ALS in your application. The position is open until filled but, for full consideration, please apply before July 15, 2013

In order to comply with the Italian law (art. 23 of Privacy Law of the Italian Legislative Decree n. 196/03), we kindly ask every candidate to provide his/her consent to allow IIT to process his/her personal data. We inform you that the information you provided will be used solely for the purpose of assessing your professional profile to meet the requirements of Istituto Italiano di Tecnologia. Your data will be processed by Istituto Italiano di Tecnologia, with headquarters in Genoa, Via Morego, 30, acting as the Data Holder, using computer and paper based means, observing the rules on protection of personal data, including those relating to the security of data. Please also note that, pursuant to art. 7 of Legislative Decree 196/2003, you may exercise your rights at any time as a party concerned by contacting the Data Manager.

The Istituto Italiano di Tecnologia is an Equal Opportunity Employer that actively seeks diversity in the workforce.

Center for Life Nano Science Viale Regina Elena 291, 00161 Roma
Copyright © 2012 Istituto Italiano di Tecnologia (IIT). Via Morego, 30 16163 Genova, Italy. Tel: +39 010 71781. C.F. 97329350587 - P.I. 09198791007

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